SPEN

For other uses, see Spen (disambiguation).

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.^[5][6][7]

SPEN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OW1, 2RT5, 4P6Q
Identifiers
Aliases	SPEN, HIAA0929, MINT, RBM15C, SHARP, spen family transcriptional repressor, RATARS
External IDs	OMIM: 613484; MGI: 1891706; HomoloGene: 124461; GeneCards: SPEN; OMA:SPEN - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.21-p36.13 Start 15,836,095 bp[1] End 15,940,456 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 141,195,201 bp[2] End 141,265,908 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence optic nerve popliteal artery tibial arteries parotid gland Descending thoracic aorta right hemisphere of cerebellum Achilles tendon ascending aorta Top expressed in internal carotid artery external carotid artery Rostral migratory stream granulocyte ventricular zone genital tubercle tail of embryo crypt of lieberkuhn of small intestine visual cortex neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding nucleic acid binding RNA binding transcription corepressor activity Cellular component transcription repressor complex extracellular exosome nucleus nucleoplasm Biological process Notch signaling pathway positive regulation of neurogenesis mRNA splicing, via spliceosome viral process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23013 56381 Ensembl ENSG00000065526 ENSMUSG00000040761 UniProt Q96T58 Q62504 RefSeq (mRNA) NM_015001 NM_019763 NM_001347235 RefSeq (protein) NP_055816 NP_001334164 NP_062737 Location (UCSC) Chr 1: 15.84 – 15.94 Mb Chr 4: 141.2 – 141.27 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.^[7]

Interactions

SPEN has been shown to interact with HDAC1,^[6] SRA1^[6] and Nuclear receptor co-repressor 2.^[6]