SRA1

For the flying boat fighter aircraft, see Saunders-Roe SR.A/1.

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene.^[5][6] The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.^[7]

SRA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MGX, 4NBO
Identifiers
Aliases	SRA1, SRA, SRAP, STRAA1, pp7684, steroid receptor RNA activator 1
External IDs	OMIM: 603819; MGI: 1344414; HomoloGene: 11906; GeneCards: SRA1; OMA:SRA1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 140,537,340 bp[1] End 140,557,677 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B2 Start 36,799,734 bp[2] End 36,803,868 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell left adrenal gland left adrenal cortex right adrenal gland right adrenal cortex anterior pituitary myocardium of left ventricle cardiac muscle tissue of right atrium stromal cell of endometrium blood Top expressed in right kidney yolk sac calvaria duodenum left lobe of liver temporal muscle embryo muscle of thigh lip molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity protein binding nuclear receptor coactivator activity steroid receptor RNA activator RNA binding DNA binding Cellular component microtubule cytoskeleton intercellular bridge plasma membrane nucleus nucleoplasm cytosol cytoplasm ribonucleoprotein complex transcription regulator complex cell leading edge Biological process regulation of apoptotic process cell differentiation positive regulation of signaling receptor activity cell population proliferation regulation of transcription, DNA-templated transcription, DNA-templated apoptotic process regulation of transcription by RNA polymerase II negative regulation of myoblast differentiation cellular response to estrogen stimulus positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10011 24068 Ensembl ENSG00000213523 ENSMUSG00000006050 UniProt Q9HD15 Q80VJ2 RefSeq (mRNA) NM_001035235 NM_001253764 NM_001164406 NM_025291 RefSeq (protein) NP_001030312 NP_001240693 NP_001157878 NP_079567 Location (UCSC) Chr 5: 140.54 – 140.56 Mb Chr 18: 36.8 – 36.8 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is involved in transcriptional coactivation by steroid receptor. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.^[6]

Interactions

SRA1 has been shown to interact with:

• Estrogen receptor alpha,^{[unreliable source?]}
• DDX17,^{[unreliable source?]}
• Nuclear receptor coactivator 2,^{[unreliable source?]} and
• SPEN.^[8]

The SRAP has been shown to interact with its SRA RNA counterpart indirectly with the functional sub-structure STR7 of SRA RNA.^[9] Originally proposed to be RRM containing, SRAP has been demonstrated to have a helix bundle at its C-terminal end while N-terminal to this domain appears unstructured.^[10]