SPIB

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.^[5][6]

SPIB
Identifiers
Aliases	SPIB, SPI-B, Spi-B transcription factor
External IDs	OMIM: 606802; MGI: 892986; HomoloGene: 79220; GeneCards: SPIB; OMA:SPIB - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,418,938 bp[1] End 50,431,314 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.83 cM Start 44,175,417 bp[2] End 44,181,495 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node mucosa of transverse colon appendix granulocyte buccal mucosa cell spleen rectum mucosa of ileum epithelium of nasopharynx blood Top expressed in mesenteric lymph nodes spleen tibiofemoral joint blood granulocyte subcutaneous adipose tissue submandibular gland bone marrow thymus femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process regulation of transcription by RNA polymerase II cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6689 272382 Ensembl ENSG00000269404 ENSMUSG00000008193 UniProt Q01892 O35906 RefSeq (mRNA) NM_003121 NM_001243998 NM_001243999 NM_001244000 NM_019866 RefSeq (protein) NP_001230927 NP_001230928 NP_001230929 NP_003112 NP_063919 Location (UCSC) Chr 19: 50.42 – 50.43 Mb Chr 7: 44.18 – 44.18 Mb PubMed search [3] [4]
Wikidata
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Function

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM]^[6]

Interactions

SPIB has been shown to interact with MAPK3^[7] and MAPK8.^[7]