SPRED2

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.^[5]

SPRED2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JP2
Identifiers
Aliases	SPRED2, Spred-2, sprouty related EVH1 domain containing 2, NS14
External IDs	OMIM: 609292; MGI: 2150019; HomoloGene: 24918; GeneCards: SPRED2; OMA:SPRED2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p14 Start 65,310,851 bp[1] End 65,432,637 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A3.1 Start 19,874,375 bp[2] End 19,974,026 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve mucosa of sigmoid colon ventricular zone cartilage tissue epithelium of colon gonad postcentral gyrus prefrontal cortex superior frontal gyrus Brodmann area 46 Top expressed in tail of embryo primitive streak prefrontal cortex cingulate gyrus genital tubercle hair follicle primary motor cortex hippocampus proper cerebellar vermis lobe of cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding protein serine/threonine kinase inhibitor activity stem cell factor receptor binding Cellular component cytoplasm plasma membrane transport vesicle membrane membrane cytoplasmic vesicle cytosol Biological process multicellular organism development negative regulation of peptidyl-threonine phosphorylation regulation of signal transduction fibroblast growth factor receptor signaling pathway regulation of protein deacetylation positive regulation of DNA damage response, signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200734 114716 Ensembl ENSG00000198369 ENSMUSG00000045671 UniProt Q7Z698 Q924S7 RefSeq (mRNA) NM_001128210 NM_181784 NM_033523 RefSeq (protein) NP_001121682 NP_861449 NP_277058 Location (UCSC) Chr 2: 65.31 – 65.43 Mb Chr 11: 19.87 – 19.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SPRED2 is a member of the Sprouty (see SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1^[5]).