SRSF2

Serine/arginine-rich splicing factor 2 is a protein that in humans is encoded by the SRSF2 gene.^[5][6][7] MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.^[8]

SRSF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KN4, 2LEA, 2LEB, 2LEC
Identifiers
Aliases	SRSF2, PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b, serine/arginine-rich splicing factor 2, serine and arginine rich splicing factor 2
External IDs	OMIM: 600813; MGI: 98284; HomoloGene: 37721; GeneCards: SRSF2; OMA:SRSF2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,734,115 bp[1] End 76,737,333 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E2|11 81.49 cM Start 116,849,901 bp[2] End 116,853,094 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia embryo tendon of biceps brachii thymus ventricular zone ganglionic eminence granulocyte male germ cell sperm lymph node Top expressed in corneal stroma otic placode tail of embryo otic vesicle Ileal epithelium superior surface of tongue genital tubercle medial ganglionic eminence saccule lactiferous gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity protein binding nucleic acid binding RNA binding protein kinase C binding pre-mRNA binding Cellular component PML body nuclear speck nucleoplasm extracellular exosome nucleus cytosol spliceosomal complex interchromatin granule cytoplasm Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA export from nucleus RNA splicing mRNA 3'-end processing RNA export from nucleus negative regulation of nucleic acid-templated transcription mitotic cell cycle regulation of alternative mRNA splicing, via spliceosome response to vitamin E regulation of RNA splicing mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6427 20382 Ensembl ENSG00000161547 ENSMUSG00000034120 UniProt Q01130 Q62093 RefSeq (mRNA) NM_001195427 NM_003016 NM_011358 RefSeq (protein) NP_001182356 NP_003007 NP_035488 Location (UCSC) Chr 17: 76.73 – 76.74 Mb Chr 11: 116.85 – 116.85 Mb PubMed search [3] [4]
Wikidata
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Interactions

SFRS2 has been shown to interact with CDC5L^[9] and ASF/SF2.^[10]