SS18

Protein SSXT is a protein that in humans is encoded by the SS18 gene.^[5][6][7]

SS18
Identifiers
Aliases	SS18, SSXT, SYT, nBAF chromatin remodeling complex subunit, SS18 subunit of BAF chromatin remodeling complex, SMARCL1
External IDs	OMIM: 600192; MGI: 107708; HomoloGene: 38080; GeneCards: SS18; OMA:SS18 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 26,016,253 bp[1] End 26,091,217 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 14,757,255 bp[2] End 14,815,971 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex stromal cell of endometrium left ovary Achilles tendon left adrenal gland right ovary left adrenal cortex skin of abdomen gallbladder tibial nerve Top expressed in zygote ventricular zone esophagus tail of embryo genital tubercle lip yolk sac right kidney morula blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear receptor coactivator activity transcription coactivator activity Cellular component cytoplasmic microtubule npBAF complex nucleus SWI/SNF complex Biological process ephrin receptor signaling pathway intracellular signal transduction regulation of transcription, DNA-templated cytoskeleton organization microtubule cytoskeleton organization cell morphogenesis transcription, DNA-templated positive regulation of transcription by RNA polymerase II neuronal stem cell population maintenance positive regulation of transcription, DNA-templated regulation of nucleic acid-templated transcription positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6760 268996 Ensembl ENSG00000141380 ENSMUSG00000037013 UniProt Q15532 Q4VAX0 Q62280 RefSeq (mRNA) NM_001007559 NM_001308201 NM_005637 NM_001161369 NM_001161370 NM_001161371 NM_009280 RefSeq (protein) NP_001007560 NP_001295130 NP_005628 NP_005628.2 NP_001154841 NP_001154842 NP_001154843 NP_033306 Location (UCSC) Chr 18: 26.02 – 26.09 Mb Chr 18: 14.76 – 14.82 Mb PubMed search [3] [4]
Wikidata
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Function

SS18 is a member of the human SWI/SNF chromatin remodeling complex.^[8][9][10]

Clinical significance

SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma.^[11]

Interactions

SS18 has been shown to interact with:

• EP300,^[12]
• MLLT10,^[13]
• SMARCA2,^[10] and
• SMARCB1.^[9]