SSX5

Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.^[3]

SSX5
Identifiers
Aliases	SSX5, SSX family member 5
External IDs	OMIM: 300327; HomoloGene: 137346; GeneCards: SSX5; OMA:SSX5 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 48,186,220 bp[1] End 48,196,795 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle right uterine tube pharynx human musculoskeletal system tonsil placenta renal cortex muscular system muscle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transcription corepressor activity nucleic acid binding Cellular component intracellular anatomical structure nucleus Biological process negative regulation of nucleic acid-templated transcription regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6758 n/a Ensembl ENSG00000165583 n/a UniProt O60225 n/a RefSeq (mRNA) NM_021015 NM_175723 n/a RefSeq (protein) NP_066295 NP_783729 n/a Location (UCSC) Chr X: 48.19 – 48.2 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.^[3]