STAB1

Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.^[5][6][7]

STAB1
Identifiers
Aliases	STAB1, CLEVER-1, FEEL-1, FELE-1, FEX1, STAB-1, SCARH2, stabilin 1, FEEL1
External IDs	OMIM: 608560; MGI: 2178742; HomoloGene: 9035; GeneCards: STAB1; OMA:STAB1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.1 Start 52,495,338 bp[1] End 52,524,495 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 B Start 31,139,013 bp[2] End 31,168,641 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen right adrenal cortex right coronary artery left adrenal cortex gastric mucosa apex of heart left coronary artery left uterine tube tibial nerve upper lobe of left lung Top expressed in stroma of bone marrow endothelial cell of lymphatic vessel internal carotid artery external carotid artery umbilical cord yolk sac dermis tunica adventitia of aorta aortic valve left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-disulfide reductase activity low-density lipoprotein particle receptor activity scavenger receptor activity protein binding hyaluronic acid binding low-density lipoprotein particle binding calcium ion binding Cellular component integral component of membrane endocytic vesicle membrane plasma membrane integral component of plasma membrane membrane Biological process negative regulation of angiogenesis cell-cell signaling cell adhesion inflammatory response defense response to bacterium receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23166 192187 Ensembl ENSG00000010327 ENSMUSG00000042286 UniProt Q9NY15 Q8R4Y4 RefSeq (mRNA) NM_015136 NM_138672 RefSeq (protein) NP_055951 n/a Location (UCSC) Chr 3: 52.5 – 52.52 Mb Chr 14: 31.14 – 31.17 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes.^[7] STAB1 is also known to interact with the protein chitinase domain-containing protein 1.