STAM2

Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene.^[5][6][7]

STAM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X2Q, 1X5B, 2L0T, 5CRV
Identifiers
Aliases	STAM2, Hbp, STAM2A, STAM2B, signal transducing adaptor molecule 2
External IDs	OMIM: 606244; MGI: 1929100; HomoloGene: 68490; GeneCards: STAM2; OMA:STAM2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q23.3 Start 152,116,801 bp[1] End 152,175,763 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.1 Start 52,581,676 bp[2] End 52,632,293 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii Achilles tendon mucosa of paranasal sinus bronchial epithelial cell epithelium of nasopharynx internal globus pallidus oocyte buccal mucosa cell superficial temporal artery secondary oocyte Top expressed in spermatid spermatocyte morula morula pineal gland median eminence epithelium of stomach habenula neural layer of retina seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm ESCRT-0 complex endosome early endosome membrane intracellular membrane-bounded organelle membrane nucleoplasm cytosol Biological process protein transport endosomal transport multivesicular body assembly intracellular protein transport negative regulation of epidermal growth factor receptor signaling pathway macroautophagy membrane organization protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10254 56324 Ensembl ENSG00000115145 ENSMUSG00000055371 UniProt O75886 O88811 RefSeq (mRNA) NM_005843 NM_019667 RefSeq (protein) NP_005834 NP_062641 Location (UCSC) Chr 2: 152.12 – 152.18 Mb Chr 2: 52.58 – 52.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.^[7]

Interactions

STAM2 has been shown to interact with HGS,^[8][9] Janus kinase 1^[5][6] and USP8.^[10][11]