STARD3NL

MENTHO or STARD3 N-terminal like protein (STARD3NL) is an integral membrane protein of unknown function.^[5] As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also known as MLN64, but lacks the StAR-related transfer domain (START) that characterizes all other proteins given the "STARD" (START domain-containing) name. The N-terminal domain is called a MENTAL (MLN64 N-terminal) domain.

STARD3NL
Identifiers
Aliases	STARD3NL, MENTHO, STARD3 N-terminal like
External IDs	OMIM: 611759; MGI: 1923455; HomoloGene: 11501; GeneCards: STARD3NL; OMA:STARD3NL - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.1 Start 38,178,245 bp[1] End 38,230,670 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A2 Start 19,357,676 bp[2] End 19,395,795 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte pancreatic epithelial cell endothelial cell mucosa of ileum islet of Langerhans ganglionic eminence hypothalamus C1 segment ventricular zone substantia nigra Top expressed in basilar part of occipital bone splanchnocranium zygote hyoid bone right kidney rib yolk sac secondary oocyte endocardial cushion seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cholesterol binding protein homodimerization activity Cellular component lysosomal membrane membrane integral component of membrane endosome cytosol intracellular membrane-bounded organelle endoplasmic reticulum membrane late endosome membrane organelle membrane contact site endoplasmic reticulum-endosome membrane contact site Biological process C21-steroid hormone biosynthetic process vesicle tethering to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83930 76205 Ensembl ENSG00000010270 ENSMUSG00000003062 UniProt O95772 Q9DCI3 RefSeq (mRNA) NM_032016 NM_001363339 NM_001363340 NM_001363343 NM_001363344 NM_001363345 NM_001363346 NM_001363347 NM_024270 NM_001347485 RefSeq (protein) NP_114405 NP_001350268 NP_001350269 NP_001350272 NP_001350273 NP_001350274 NP_001350275 NP_001350276 NP_001334414 NP_077232 Location (UCSC) Chr 7: 38.18 – 38.23 Mb Chr 13: 19.36 – 19.4 Mb PubMed search [3] [4]
Wikidata
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Like MLN64, MENTHO is widely expressed in tissues of the body. Within the cell, it localizes to the membranes of late endosomes and may interact there with MLN64. It is suggested that in combination with MLN64, this protein helps regulate the flow of cholesterol through the endosomal pathway.^[6]