STK35L1

STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene.^[5] It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome. Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells.^[6][7] Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1.

STK35
Identifiers
Aliases	STK35, serine/threonine kinase 35, CLIK1, STK35L1, Serine/threonine kinase 35
External IDs	OMIM: 609370; MGI: 1914583; HomoloGene: 15441; GeneCards: STK35; OMA:STK35 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 2,101,827 bp[1] End 2,177,038 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 129,642,437 bp[2] End 129,674,207 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell Brodmann area 23 amniotic fluid parietal pleura pancreatic epithelial cell gingival epithelium parotid gland visceral pleura palpebral conjunctiva Top expressed in neural layer of retina zygote secondary oocyte primary oocyte spermatid Meckel's cartilage ascending aorta occiput spermatocyte Gonadal ridge More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity Cellular component cytoplasm nucleolus nucleus nuclear body Biological process protein phosphorylation phosphorylation meiosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140901 67333 Ensembl ENSG00000125834 ENSMUSG00000037885 UniProt Q8TDR2 Q80ZW0 RefSeq (mRNA) NM_080836 NM_001038635 NM_183262 RefSeq (protein) NP_543026 NP_001033724 NP_899085 Location (UCSC) Chr 20: 2.1 – 2.18 Mb Chr 2: 129.64 – 129.67 Mb PubMed search [3] [4]
Wikidata
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Functions

STK35L1 is predominantly found in the nucleus and the nucleolus. Nuclear actin was identified as a novel binding partner of STK35L1.^[8] However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition. Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.