SUB1

Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene.^[5][6][7] The human SUB1 gene^[7] is named after an orthologous gene in yeast.^[8]

SUB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PCF, 2C62, 2PHE, 4USG
Identifiers
Aliases	SUB1, P15, PC4, p14, SUB1 homolog, transcriptional regulator, SUB1 regulator of transcription
External IDs	OMIM: 600503; MGI: 104811; HomoloGene: 38218; GeneCards: SUB1; OMA:SUB1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.3 Start 32,531,633 bp[1] End 32,604,079 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 A1 Start 11,981,425 bp[2] End 11,997,069 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx lactiferous duct epithelium of colon ganglionic eminence gingival epithelium parotid gland bone marrow cell germinal epithelium endometrium ventricular zone Top expressed in genital tubercle tail of embryo yolk sac abdominal wall primitive streak neural tube gastrula medial ganglionic eminence migratory enteric neural crest cell embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded DNA binding DNA binding transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific protein binding RNA binding identical protein binding sequence-specific double-stranded DNA binding Cellular component nucleolus extracellular exosome transcription regulator complex nucleus Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription by RNA polymerase II SMAD protein signal transduction transcription, DNA-templated positive regulation of transcription initiation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10923 20024 Ensembl ENSG00000113387 ENSMUSG00000022205 UniProt P53999 P11031 RefSeq (mRNA) NM_006713 NM_011294 RefSeq (protein) NP_006704 NP_035424 Location (UCSC) Chr 5: 32.53 – 32.6 Mb Chr 15: 11.98 – 12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SUB1 is induced by oxidative stress, and is involved in coordinating cellular responses to DNA strand breaks that arise after oxidative stress.Yu L, Ma H, Ji X, Volkert MR (January 2016). "The Sub1 nuclear protein protects DNA from oxidative damage". Molecular and Cellular Biochemistry. 412 (1–2): 165–171. doi:10.1007/s11010-015-2621-x. PMC 5064834. PMID 26708217. Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson's disease.Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, et al. (July 2019). "Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders". Scientific Reports. 9 (1): 10919. doi:10.1038/s41598-019-47227-z. PMC 6662836. PMID 31358782. Like SUB1, alpha-synuclein functions in regulating DNA repair including repair of DNA double-strand breaks.

Interactions

SUB1 has been shown to interact with CSTF2.^[9]