SUDS3

Sin3 histone deacetylase corepressor complex component SDS3 is an enzyme that in humans is encoded by the SUDS3 gene.^[5][6]

SUDS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2N2H, 4ZQA
Identifiers
Aliases	SUDS3, SAP45, SDS3, SDS3 homolog, SIN3A corepressor complex component
External IDs	OMIM: 608250; MGI: 1919204; HomoloGene: 15906; GeneCards: SUDS3; OMA:SUDS3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 118,376,555 bp[1] End 118,418,033 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 117,229,745 bp[2] End 117,254,178 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell palpebral conjunctiva pancreatic epithelial cell epithelium of colon parotid gland skin of arm tonsil germinal epithelium bone marrow cell Top expressed in spermatid spermatocyte saccule neural layer of retina blood otic placode otic vesicle granulocyte lens lip More reference expression data BioGPS n/a
Gene ontology Molecular function histone deacetylase binding protein binding enzyme binding histone deacetylase activity Cellular component Sin3 complex nucleoplasm Sin3-type complex nucleus cytosol nuclear body Biological process regulation of transcription, DNA-templated substantia nigra development negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of apoptotic process negative regulation of transcription, DNA-templated histone deacetylation apoptotic process protein deubiquitination chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64426 71954 Ensembl ENSG00000111707 ENSMUSG00000066900 UniProt Q9H7L9 Q8BR65 RefSeq (mRNA) NM_022491 NM_001122666 NM_178622 RefSeq (protein) NP_071936 NP_001116138 NP_848737 Location (UCSC) Chr 12: 118.38 – 118.42 Mb Chr 5: 117.23 – 117.25 Mb PubMed search [3] [4]
Wikidata
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Function

SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM]^[6]

Interactions

SUDS3 has been shown to interact with HDAC1,^[5][7] Host cell factor C1,^[8] SIN3B^[5] and SIN3A.^[5][7]