SIN3B

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.^[5][6]

SIN3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E91, 1PD7, 2CR7, 2CZY, 2F05
Identifiers
Aliases	SIN3B, Paired amphipathic helix protein Sin3b, SIN3 transcription regulator family member B
External IDs	OMIM: 607777; MGI: 107158; HomoloGene: 81810; GeneCards: SIN3B; OMA:SIN3B - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 16,829,398 bp[1] End 16,880,353 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 35.08 cM Start 73,449,913 bp[2] End 73,484,829 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus right uterine tube right ovary left ovary canal of the cervix right lung gastric mucosa left uterine tube left testis sural nerve Top expressed in Gonadal ridge Paneth cell internal carotid artery external carotid artery fossa renal corpuscle epithelium of lens condyle endocardial cushion medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity histone deacetylase activity chromatin binding protein binding Cellular component cytoplasm X chromosome Y chromosome autosome Sin3 complex nucleoplasm XY body nucleus chromatin Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of transcription, DNA-templated histone deacetylation regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23309 20467 Ensembl ENSG00000127511 ENSMUSG00000031622 UniProt O75182 Q62141 RefSeq (mRNA) NM_001297595 NM_001297597 NM_015260 NM_001113248 NM_009188 RefSeq (protein) NP_001284524 NP_001284526 NP_056075 NP_001106719 NP_033214 Location (UCSC) Chr 19: 16.83 – 16.88 Mb Chr 8: 73.45 – 73.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SIN3B has been shown to interact with HDAC1,^[7][8] Zinc finger and BTB domain-containing protein 16,^[9] SUDS3^[10] and IKZF1.^[8][11]

See also

• Transcription coregulator