Bile salt sulfotransferase

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.^[5][6][7]

SULT2A1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1EFH, 1J99, 1OV4, 2QP3, 2QP4, 3F3Y, 4IFB
Identifiers
Aliases	SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa, sulfotransferase family 2A member 1, DHEA-ST8, SULT2A3
External IDs	OMIM: 125263; MGI: 3645854; HomoloGene: 37741; GeneCards: SULT2A1; OMA:SULT2A1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 47,870,467 bp[1] End 47,886,315 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 13,643,601 bp[2] End 13,723,532 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex jejunal mucosa right lobe of liver left adrenal cortex duodenum gonad buccal mucosa cell seminal vesicula cardia mucosa of ileum Top expressed in primary oocyte zygote secondary oocyte spermatocyte spermatid gonad testicle liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity protein binding estrone sulfotransferase activity aryl sulfotransferase activity steroid sulfotransferase activity bile-salt sulfotransferase activity Cellular component cytoplasm cytosol Biological process lipid catabolic process bile acid catabolic process sulfation lipid metabolism ethanol catabolic process regulation of lipid metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process steroid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6822 434121 Ensembl ENSG00000105398 ENSMUSG00000074377 UniProt Q06520 n/a RefSeq (mRNA) NM_003167 NM_001101534 RefSeq (protein) NP_003158 n/a Location (UCSC) Chr 19: 47.87 – 47.89 Mb Chr 7: 13.64 – 13.72 Mb PubMed search [3] [4]
Wikidata
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Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.^[5]

See also

• Steroid sulfotransferase
• Steroidogenic enzyme