SULT2B1

Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene.^[5][6]

SULT2B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q1Q, 1Q1Z, 1Q20, 1Q22
Identifiers
Aliases	SULT2B1, HSST2, sulfotransferase family 2B member 1, ARCI14
External IDs	OMIM: 604125; MGI: 1926342; HomoloGene: 49487; GeneCards: SULT2B1; OMA:SULT2B1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,552,172 bp[1] End 48,599,425 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,379,407 bp[2] End 45,434,093 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg gingival epithelium skin of arm mucosa of pharynx oral cavity vulva skin of thigh epithelium of esophagus cervix epithelium Top expressed in lip esophagus jejunum duodenum skin of abdomen skin of external ear intestinal villus ileum skin of back epidermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity protein binding alcohol sulfotransferase activity steroid sulfotransferase activity nucleic acid binding cholesterol binding steroid hormone binding Cellular component extracellular exosome endoplasmic reticulum intracellular membrane-bounded organelle nucleus cytoplasm cytosol Biological process steroid metabolic process sulfate assimilation lipid metabolism 3'-phosphoadenosine 5'-phosphosulfate metabolic process cholesterol metabolic process negative regulation of cell population proliferation positive regulation of epidermal cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6820 54200 Ensembl ENSG00000088002 ENSMUSG00000003271 UniProt O00204 O35400 RefSeq (mRNA) NM_004605 NM_177973 NM_017465 NM_001360784 RefSeq (protein) NP_004596 NP_814444 NP_059493 NP_001347713 Location (UCSC) Chr 19: 48.55 – 48.6 Mb Chr 7: 45.38 – 45.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic chemical compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.^[6]

See also

• Steroid sulfotransferase
• Steroidogenic enzyme