SUPT4H1

Transcription elongation factor SPT4 is a protein that in humans is encoded by the SUPT4H1 gene.^[4][5] Together with hSPT5, it composes DSIF in humans.^[6]

SUPT4H1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H7H
Identifiers
Aliases	SUPT4H1, SPT4, SPT4H, SUPT4H, Supt4a, SPT4 homolog, DSIF elongation factor subunit
External IDs	OMIM: 603555; MGI: 107416; HomoloGene: 68303; GeneCards: SUPT4H1; OMA:SUPT4H1 - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse)[1] Band 11 C|11 52.2 cM Start 87,628,378 bp[1] End 87,634,449 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood Achilles tendon bone marrow stromal cell of endometrium lymph node islet of Langerhans ganglionic eminence bone marrow cell right adrenal gland Top expressed in granulocyte morula embryo embryo yolk sac ventricular zone right kidney neural layer of retina lip dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity zinc ion binding metal ion binding protein binding protein heterodimerization activity RNA polymerase II complex binding single-stranded RNA binding Cellular component nucleoplasm DSIF complex nucleus Biological process chromatin remodeling regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of transcription elongation from RNA polymerase II promoter transcription, DNA-templated negative regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription, elongation positive regulation of transcription by RNA polymerase II mRNA processing regulation of transcription elongation from RNA polymerase II promoter chromatin organization positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6827 20922 Ensembl n/a ENSMUSG00000020485 UniProt P63272 P63271 RefSeq (mRNA) NM_003168 NM_009296 NM_001355753 RefSeq (protein) NP_003159 NP_033322 NP_001342682 Location (UCSC) n/a Chr 11: 87.63 – 87.63 Mb PubMed search [2] [3]
Wikidata
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