SUPT5H

Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.^[5][6] Together with hSPT4, it composes DSIF in humans.^[7]

SUPT5H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO3, 2E6Z, 2E70, 3H7H, 4L1U
Identifiers
Aliases	SUPT5H, SPT5, SPT5H, Tat-CT1, SPT5 homolog, DSIF elongation factor subunit
External IDs	OMIM: 602102; MGI: 1202400; HomoloGene: 2384; GeneCards: SUPT5H; OMA:SUPT5H - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 39,436,156 bp[1] End 39,476,670 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 16.68 cM Start 28,014,316 bp[2] End 28,038,171 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis anterior pituitary sural nerve right hemisphere of cerebellum right lobe of thyroid gland right uterine tube left lobe of thyroid gland apex of heart right frontal lobe Top expressed in adrenal gland Gonadal ridge internal carotid artery external carotid artery fossa crypt of lieberkuhn of small intestine lacrimal gland tail of embryo vestibular membrane of cochlear duct motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein heterodimerization activity enzyme binding chromatin binding RNA binding DNA binding mRNA binding Cellular component nucleoplasm DSIF complex nucleus Biological process chromatin remodeling negative regulation of mRNA polyadenylation regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter regulation of DNA-templated transcription, elongation negative regulation of transcription by RNA polymerase II 7-methylguanosine mRNA capping transcription by RNA polymerase II response to organic substance transcription, DNA-templated negative regulation of DNA-templated transcription, elongation positive regulation of DNA-templated transcription, elongation positive regulation of macroautophagy DNA-templated transcription, elongation single stranded viral RNA replication via double stranded DNA intermediate positive regulation of viral transcription cell cycle positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6829 20924 Ensembl ENSG00000196235 ENSMUSG00000003435 UniProt O00267 O55201 RefSeq (mRNA) NM_001111020 NM_001130824 NM_001130825 NM_003169 NM_001319990 NM_001319991 NM_013676 RefSeq (protein) NP_001104490 NP_001124296 NP_001124297 NP_001306919 NP_001306920 NP_003160 NP_038704 Location (UCSC) Chr 19: 39.44 – 39.48 Mb Chr 7: 28.01 – 28.04 Mb PubMed search [3] [4]
Wikidata
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Interactions

SUPT5H has been shown to interact with:

• CDK9,^[8]
• Cyclin-dependent kinase 7,^[8]
• HTATSF1,^[9]
• PIN1,^[10]
• POLR2A,^[9][11]
• PRMT1^[12] and
• Protein arginine methyltransferase 5.^[12]