SYCP3

Synaptonemal complex protein 3 is a protein that in humans is encoded by the SYCP3 gene.^[5][6][7] It is a component of the synaptonemal complex formed between homologous chromosomes during the prophase of meiosis.^[8]

SYCP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CPC
Identifiers
Aliases	SYCP3, COR1, SCP3, SPGF4, RPRGL4, synaptonemal complex protein 3
External IDs	OMIM: 604759; MGI: 109542; HomoloGene: 7964; GeneCards: SYCP3; OMA:SYCP3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.2 Start 101,728,648 bp[1] End 101,739,472 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 88,295,431 bp[2] End 88,309,098 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis secondary oocyte gonad sperm testicle buccal mucosa cell stromal cell of endometrium mucosa of transverse colon Achilles tendon Top expressed in seminiferous tubule spermatocyte spermatid ascending aorta zygote aortic valve epithelium of small intestine Gonadal ridge brown adipose tissue secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding Cellular component nucleus chromosome synaptonemal complex lateral element chromosome, centromeric region Biological process cell cycle male meiosis I cell division meiosis spermatogenesis spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50511 20962 Ensembl ENSG00000139351 ENSMUSG00000020059 UniProt Q8IZU3 P70281 RefSeq (mRNA) NM_001177948 NM_001177949 NM_153694 NM_011517 RefSeq (protein) NP_001171419 NP_001171420 NP_710161 NP_035647 Location (UCSC) Chr 12: 101.73 – 101.74 Mb Chr 10: 88.3 – 88.31 Mb PubMed search [3] [4]
Wikidata
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Gene family

XLR/SYCP3/FAM9 domain Identifiers Symbol Cor1 Pfam PF04803 InterPro IPR006888 CATH 4cpc Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

SYCP3 is also known as COR1. It contains a conserved coiled-coil domain that is also found in the FAM9 (FAM9A, FAM9B) family of proteins, found on the human X chromosome.^[5]

Several SYCP3-like proteins are found on mice sex chromosomes. They are assigned names starting with Slx or Sly depending on the chromosome they are linked to. Slx/Slxl1 and Sly are neofunctionalized ones that have opposite effects on gene expression and epigenetic modifications, and each gene reduces the viability and mobility (via spindlin binding) of sperms containing the other sex chromosome, tilting the sex ratio to their own favor.^[9] Over time they are duplicated to balance out each other's effects.^[10]