Signal transducing adaptor molecule

Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.^[5][6]

STAM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L0A, 3F1I, 3LDZ
Identifiers
Aliases	STAM, STAM-1, STAM1, Signal transducing adaptor molecule
External IDs	OMIM: 601899; MGI: 1329014; HomoloGene: 37788; GeneCards: STAM; OMA:STAM - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.33 Start 17,644,151 bp[1] End 17,716,824 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A2 Start 14,078,909 bp[2] End 14,154,445 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon amniotic fluid endothelial cell retinal pigment epithelium corpus callosum Brodmann area 23 pars compacta germinal epithelium Pons ganglionic eminence Top expressed in tail of embryo genital tubercle ganglionic eminence perirhinal cortex entorhinal cortex CA3 field superior frontal gyrus medial ganglionic eminence ventricular zone dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin-like protein ligase binding Cellular component cytoplasm cytosol endosome early endosome membrane membrane ESCRT-0 complex Biological process negative regulation of epidermal growth factor receptor signaling pathway regulation of extracellular exosome assembly multivesicular body assembly endosomal transport protein transport positive regulation of exosomal secretion intracellular protein transport signal transduction positive regulation of signal transduction macroautophagy protein deubiquitination membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8027 20844 Ensembl ENSG00000136738 ENSMUSG00000026718 UniProt Q92783 P70297 RefSeq (mRNA) NM_003473 NM_001324282 NM_001324283 NM_001324284 NM_001324285 NM_001324286 NM_001324287 NM_001324288 NM_001324289 NM_011484 NM_001356337 RefSeq (protein) NP_001311211 NP_001311212 NP_001311213 NP_001311214 NP_001311215 NP_001311216 NP_001311217 NP_001311218 NP_003464 NP_035614 NP_001343266 Location (UCSC) Chr 10: 17.64 – 17.72 Mb Chr 2: 14.08 – 14.15 Mb PubMed search [3] [4]
Wikidata
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Function

This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.^[6] STAM1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.^[7]

Interactions

Signal transducing adaptor molecule has been shown to interact with

• HGS,^[8][9][10]
• Janus kinase 2.^[11]
• MAP3K1,^[12]
• STAMBP,^[13][14] and
• TIMM8A.^[15]