S-phase kinase-associated protein 1

S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene.^[5][6][7]

SKP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FQV, 1FS1, 1FS2, 1LDK, 1P22, 2ASS, 2AST, 2E31, 2E32, 2OVP, 2OVQ, 2OVR, 3L2O, 3WSO, 4I6J, 5IBK
Identifiers
Aliases	SKP1, EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A, S-phase kinase-associated protein 1, S-phase kinase associated protein 1
External IDs	OMIM: 601434; MGI: 103575; HomoloGene: 38775; GeneCards: SKP1; OMA:SKP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 134,148,935 bp[1] End 134,176,964 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 31.86 cM Start 52,122,822 bp[2] End 52,137,685 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex right hemisphere of cerebellum right frontal lobe right testis pons left testis Brodmann area 9 ganglionic eminence right adrenal gland C1 segment Top expressed in vestibular membrane of cochlear duct primary oocyte olfactory epithelium spermatocyte spermatid medial ganglionic eminence secondary oocyte facial motor nucleus anterior horn of spinal cord embryonic cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cullin family protein binding beta-catenin binding ubiquitin protein ligase activity protein binding ubiquitin-protein transferase activity protein domain specific binding Cellular component cytoplasm nucleoplasm PcG protein complex nucleus cytosol SCF ubiquitin ligase complex Cul7-RING ubiquitin ligase complex centrosome Biological process ubiquitin-dependent protein catabolic process histone H2A monoubiquitination NIK/NF-kappaB signaling G2/M transition of mitotic cell cycle stress-activated MAPK cascade protein ubiquitination protein polyubiquitination Wnt signaling pathway SCF complex assembly negative regulation of G2/M transition of mitotic cell cycle maintenance of protein location in nucleus cellular iron ion homeostasis post-translational protein modification interleukin-1-mediated signaling pathway SCF-dependent proteasomal ubiquitin-dependent protein catabolic process viral process regulation of mitotic cell cycle phase transition stimulatory C-type lectin receptor signaling pathway Fc-epsilon receptor signaling pathway T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6500 21402 Ensembl ENSG00000113558 ENSMUSG00000036309 UniProt P63208 Q9WTX5 RefSeq (mRNA) NM_170679 NM_006930 NM_011543 RefSeq (protein) NP_008861 NP_733779 NP_035673 Location (UCSC) Chr 5: 134.15 – 134.18 Mb Chr 11: 52.12 – 52.14 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis.^[8] The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Interactions

SKP1A has been shown to interact with:

• BTRC,^{[9][10][11][12][13]}
• CACYBP,^[14]
• CDCA3,^[15]
• CDK9,^[16]
• CUL1,^{[10][17][18][19][20]}
• FBXL3,^[9]
• FBXO4,^[9][21]
• FBXO5,^[9]
• FBXO7,^[9]
• FBXW2,^[9]
• FBXW7,^[17][22] and
• SKP2.^{[9][10][11][23][24][25]}