Nuclear receptor coactivator 1

The nuclear receptor coactivator 1 (NCOA1), also called steroid receptor coactivator-1 (SRC-1), is a transcriptional coregulatory protein that contains several nuclear receptor–interacting domains and possesses intrinsic histone acetyltransferase activity.^[5][6] It is encoded by the gene NCOA1.^[7]

NCOA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FM6, 1FM9, 1K74, 1K7L, 1KV6, 1K4W, 1N4H, 1NQ7, 1NRL, 1P8D, 1PZL, 1RDT, 1TFC, 1U3R, 1U3S, 1X76, 1XIU, 1XV9, 1XVP, 1YY4, 1ZAF, 2A3I, 2C52, 2FVJ, 2GTK, 2HBH, 2HC4, 2HCD, 2HFP, 2NPA, 2NV7, 2P54, 2PRG, 3BEJ, 3BQD, 3CTB, 3CWD, 3DCT, 3DCU, 3DR1, 3ET1, 3ET3, 3FEI, 3FEJ, 3FUR, 3FXV, 3G8I, 3G9E, 3GYT, 3GYU, 3H0A, 3HC5, 3HC6, 3HVL, 3IPQ, 3IPS, 3IPU, 3KMR, 3LMP, 3OKH, 3OKI, 3OLF, 3OLL, 3OLS, 3OMK, 3OMM, 3OMO, 3OMP, 3OMQ, 3OOF, 3OOK, 3P88, 3P89, 3QT0, 3RUT, 3RUU, 3RVF, 3S9S, 3T03, 3UU7, 3UUA, 3UUD, 3V9Y, 3VN2, 4DK7, 4DK8, 4DM6, 4DM8, 4DQM, 4F9M, 4FGY, 4G1D, 4G1Y, 4G1Z, 4G20, 4G21, 4G2H, 4HEE, 4J5X, 4JYG, 4JYH, 4JYI, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4TUZ, 4TV1, 5AVI, 5AVL, 4Y29, 4RUJ, 4RUP, 5A86, 5E7V, 4UDB, 4UDA, 5AZT, 5HJS
Identifiers
Aliases	NCOA1, F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74, nuclear receptor coactivator 1
External IDs	OMIM: 602691; MGI: 1276523; HomoloGene: 7859; GeneCards: NCOA1; OMA:NCOA1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 24,491,254 bp[1] End 24,770,702 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 4,247,362 bp[2] End 4,477,182 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus middle frontal gyrus paraflocculus of cerebellum Brodmann area 23 entorhinal cortex tibialis anterior muscle postcentral gyrus frontal pole endothelial cell Region I of hippocampus proper Top expressed in Rostral migratory stream retinal pigment epithelium lateral septal nucleus dentate gyrus of hippocampal formation granule cell lateral geniculate nucleus anterior amygdaloid area motor neuron ventromedial nucleus mammillary body subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding transcription coactivator activity protein dimerization activity protein N-terminus binding transcription factor binding chromatin binding histone acetyltransferase activity protein binding androgen receptor binding enzyme binding acyltransferase activity nuclear receptor coactivator activity aryl hydrocarbon receptor binding nuclear receptor binding estrogen receptor binding DNA-binding transcription factor activity, RNA polymerase II-specific progesterone receptor binding retinoic acid receptor binding protein-containing complex binding retinoid X receptor binding Cellular component nucleus nucleoplasm cytosol plasma membrane protein-containing complex cytoplasm neuron projection Biological process androgen receptor signaling pathway regulation of RNA biosynthetic process regulation of transcription, DNA-templated cellular response to Thyroglobulin triiodothyronine regulation of cellular response to drug transcription, DNA-templated positive regulation of transcription, DNA-templated labyrinthine layer morphogenesis positive regulation of neuron differentiation bile acid and bile salt transport positive regulation of apoptotic process histone H4 acetylation regulation of thyroid hormone mediated signaling pathway positive regulation of transcription by RNA polymerase II intracellular receptor signaling pathway positive regulation of transcription from RNA polymerase II promoter by galactose regulation of lipid metabolic process transcription by RNA polymerase II cellular response to hormone stimulus lactation male gonad development response to hormone cerebellum development hippocampus development hypothalamus development cerebral cortex development response to estradiol response to retinoic acid response to progesterone estrous cycle positive regulation of female receptivity male mating behavior Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8648 17977 Ensembl ENSG00000084676 ENSMUSG00000020647 UniProt Q15788 P70365 RefSeq (mRNA) NM_003743 NM_147223 NM_147233 NM_001362950 NM_001362952 NM_001362954 NM_001362955 NM_010881 RefSeq (protein) NP_003734 NP_671756 NP_671766 NP_001349879 NP_001349881 NP_001349883 NP_001349884 NP_035011 Location (UCSC) Chr 2: 24.49 – 24.77 Mb Chr 12: 4.25 – 4.48 Mb PubMed search [3] [4]
Wikidata
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NCOA1 is recruited to DNA promoter sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression as a coactivator.^[5][6]

Interactions

Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:

• Androgen receptor,^[8][9][10]
• C-Fos,^[11][12]
• C-jun,^[11][12][13]
• CIITA,^[14]
• CREB-binding protein,^[15][16]
• Cyclin D1,^[17]

• Estrogen receptor alpha,^{[15][18][19][20]}
• Glucocorticoid receptor,^[21][22]
• NFKB1,^[11][23]
• PCAF,^[24]
• PPARGC1A,^[25]
• Peroxisome proliferator-activated receptor alpha,^[26][27]
• SNW1,^[28]
• STAT3,^[29]
• STAT6,^[30][31]
• TRIP4,^[32] and
• Thyroid hormone receptor beta.^[33][34]