Syntaxin 3

Syntaxin 3, also known as STX3, is a protein^[5] which in humans is encoded by the STX3 gene.^[6][7]

STX3
Identifiers
Aliases	STX3, STX3A, Syntaxin 3, MVID2, RDMVID, DIAR12
External IDs	OMIM: 600876; MGI: 103077; HomoloGene: 80191; GeneCards: STX3; OMA:STX3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 59,713,456 bp[1] End 59,805,882 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 11,752,482 bp[2] End 11,796,767 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum right lung blood islet of Langerhans upper lobe of left lung duodenum gallbladder jejunal mucosa mucosa of colon secondary oocyte Top expressed in neural layer of retina retinal pigment epithelium ciliary body medullary collecting duct epithelium of small intestine primitive streak pineal gland iris intestinal villus ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNAP receptor activity protein binding arachidonic acid binding SNARE binding Cellular component integral component of membrane membrane cell-cell junction growth cone secretory granule vacuole dendrite SNARE complex azurophil granule specific granule apical plasma membrane neuron projection extracellular exosome lamellipodium photoreceptor cell terminal bouton ribbon synapse synaptic vesicle presynaptic membrane melanosome zymogen granule membrane plasma membrane postsynapse endomembrane system presynaptic active zone membrane Schaffer collateral - CA1 synapse glutamatergic synapse Biological process synaptic vesicle docking synaptic vesicle fusion to presynaptic active zone membrane membrane fusion vesicle docking positive regulation of protein localization to plasma membrane positive regulation of chemotaxis positive regulation of cell population proliferation positive regulation of protein localization to cell surface intracellular protein transport neurotransmitter transport neuron projection development vesicle-mediated transport positive regulation of cell adhesion long-term potentiation exocytosis vesicle fusion exocytic insertion of neurotransmitter receptor to postsynaptic membrane transport cytokine-mediated signaling pathway vesicle-mediated transport in synapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6809 20908 Ensembl ENSG00000166900 ENSMUSG00000041488 UniProt Q13277 Q64704 RefSeq (mRNA) NM_001178040 NM_004177 NM_001025307 NM_001025308 NM_001286543 NM_011502 NM_152220 NM_001360386 RefSeq (protein) NP_001171511 NP_004168 NP_001020478 NP_001273472 NP_035632 NP_689344 NP_001347315 Location (UCSC) Chr 11: 59.71 – 59.81 Mb Chr 19: 11.75 – 11.8 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the syntaxin family of cellular receptors for transport vesicles which participate in exocytosis in neutrophils.^[6] STX3 has an important role in the growth of neurites and serves as a direct target for omega-6 arachidonic acid.^[8] Mutations in Syntaxin 3 cause Microvillus inclusion disease.^[9]

Interactions

Syntaxin 3 has been shown to interact with SNAP-25,^[10][11][12] SNAP23^{[11][12][13][14]} and SNAP29.^[12]