Syntaxin binding protein 3

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.^[5][6]

STXBP3
Identifiers
Aliases	STXBP3, MUNC18-3, MUNC18C, PSP, UNC-18C, Syntaxin binding protein 3
External IDs	OMIM: 608339; MGI: 107362; HomoloGene: 5260; GeneCards: STXBP3; OMA:STXBP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 108,746,674 bp[1] End 108,809,523 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 108,700,492 bp[2] End 108,747,842 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum Achilles tendon tibia C1 segment germinal epithelium epithelium of nasopharynx inferior ganglion of vagus nerve monocyte sural nerve palpebral conjunctiva Top expressed in skin of external ear stroma of bone marrow Epithelium of choroid plexus ascending aorta sciatic nerve jejunum aortic valve retinal pigment epithelium transitional epithelium of urinary bladder lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syntaxin-1 binding protein binding syntaxin binding Cellular component cytoplasm platelet alpha granule cytosol membrane tertiary granule plasma membrane basolateral plasma membrane specific granule apical plasma membrane extracellular exosome phagocytic vesicle presynapse Biological process protein to membrane docking protein heterooligomerization neutrophil degranulation insulin secretion vesicle docking involved in exocytosis response to insulin brain development negative regulation of calcium ion-dependent exocytosis protein transport platelet aggregation vesicle-mediated transport exocytosis transport cellular glucose homeostasis negative regulation of glucose import cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6814 20912 Ensembl ENSG00000116266 ENSMUSG00000027882 UniProt O00186 Q60770 RefSeq (mRNA) NM_007269 NM_011504 RefSeq (protein) NP_009200 NP_035634 Location (UCSC) Chr 1: 108.75 – 108.81 Mb Chr 3: 108.7 – 108.75 Mb PubMed search [3] [4]
Wikidata
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Interactions

Syntaxin binding protein 3 has been shown to interact with STX2^[7] and STX4.^[7][8]