TAAR6

Trace amine associated receptor 6, also known as TAAR6, is a protein which in humans is encoded by the TAAR6 gene.^[5][6]

TAAR6
Identifiers
Aliases	TAAR6, TA4, TAR4, TAR6, TRAR4, taR-4, taR-6, trace amine associated receptor 6
External IDs	OMIM: 608923; MGI: 2685074; HomoloGene: 27874; GeneCards: TAAR6; OMA:TAAR6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.2 Start 132,570,322 bp[1] End 132,571,359 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A4 Start 23,860,507 bp[2] End 23,861,544 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence renal cortex blood temporal lobe amygdala adrenal gland human kidney Top expressed in Grüneberg ganglion nasal septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function trace-amine receptor activity G protein-coupled receptor activity signal transducer activity Cellular component plasma membrane membrane integral component of membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 319100 215855 Ensembl ENSG00000146383 ENSMUSG00000045111 UniProt Q96RI8 Q5QD13 RefSeq (mRNA) NM_175067 NM_001010828 RefSeq (protein) NP_778237 NP_001010828 Location (UCSC) Chr 6: 132.57 – 132.57 Mb Chr 10: 23.86 – 23.86 Mb PubMed search [3] [4]
Wikidata
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Function

TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.^[7][8] RNA expression analysis shows hTAAR6 is expressed in the hippocampus, where murine TAAR receptors have been shown to be involved with neurogenesis.^[9]

Computational modeling suggests TAAR6 can bind to the foul smelling compounds produced by rotting flesh, putrescine and cadaverine.^[10]

TAAR6 mutant mice have differences in behavior compared with wild-type mice.^[11] Also, they have elevated brain serotonin levels in several brain regions and enhanced hypothermic response to 5-HT1A receptor agonist 8-OH-DPAT.^[12]