TADA3L

Transcriptional adapter 3-like is a protein that in humans is encoded by the TADA3 gene.^[4][5][6] Cytogenetic location: 3p25.3 ^[7]

TADA3
Identifiers
Aliases	TADA3, ADA3, NGG1, STAF54, TADA3L, hADA3, transcriptional adaptor 3
External IDs	OMIM: 602945; MGI: 1915724; HomoloGene: 4633; GeneCards: TADA3; OMA:TADA3 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse)[1] Band 6|6 E3 Start 113,342,986 bp[1] End 113,354,844 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal gland stromal cell of endometrium prefrontal cortex right coronary artery amygdala anterior pituitary cingulate gyrus thoracic aorta ascending aorta Top expressed in zygote genital tubercle secondary oocyte seminiferous tubule tail of embryo granulocyte blastocyst ventricular zone neural tube primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding DNA-binding transcription factor activity transcription coactivator activity histone acetyltransferase activity protein binding nuclear receptor binding nuclear receptor coactivator activity thiol-dependent deubiquitinase Cellular component transcription factor TFTC complex intracellular anatomical structure mitotic spindle SAGA complex nucleoplasm nucleus Biological process regulation of protein phosphorylation regulation of transcription, DNA-templated regulation of protein stability regulation of transcription by RNA polymerase II regulation of histone deacetylation transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of tubulin deacetylation positive regulation of gene expression histone H3 acetylation intracellular estrogen receptor signaling pathway protein deubiquitination histone H4 acetylation mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10474 101206 Ensembl n/a ENSMUSG00000048930 UniProt O75528 Q8R0L9 RefSeq (mRNA) NM_001278270 NM_006354 NM_133480 NM_133481 NM_133932 NM_001372392 NM_001372393 RefSeq (protein) NP_001265199 NP_006345 NP_597814 NP_598693 NP_001359321 NP_001359322 Location (UCSC) n/a Chr 6: 113.34 – 113.35 Mb PubMed search [2] [3]
Wikidata
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Function

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. At least four alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.^[6]

Interactions

TADA3L has been shown to interact with:

• Retinoic acid receptor alpha,^[8]
• Retinoid X receptor alpha,^[8]
• TADA2L,^[5][9]
• TAF9,^[10]
• Transcription initiation protein SPT3 homolog,^[10] and
• USP5.^[9]