TAF1A

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.^[5][6]

TAF1A
Identifiers
Aliases	TAF1A, MGC:17061, RAFI48, SL1, TAFI48, TATA-box binding protein associated factor, RNA polymerase I subunit A
External IDs	OMIM: 604903; MGI: 109578; HomoloGene: 4155; GeneCards: TAF1A; OMA:TAF1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q41 Start 222,557,902 bp[1] End 222,589,933 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H5 Start 183,170,325 bp[2] End 183,191,020 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte testicle ventricular zone gonad ganglionic eminence Achilles tendon monocyte lymph node stromal cell of endometrium Top expressed in primary oocyte zygote secondary oocyte neural layer of retina Ileal epithelium spermatocyte ventricular zone Paneth cell medullary collecting duct morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding Cellular component microtubule cytoskeleton RNA polymerase I transcription regulator complex nucleus nucleoplasm Biological process transcription initiation from RNA polymerase I promoter transcription by RNA polymerase I termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9015 21339 Ensembl ENSG00000143498 ENSMUSG00000072258 UniProt Q15573 Q5JRA7 P97357 RefSeq (mRNA) NM_001201536 NM_005681 NM_139352 NM_001277957 NM_001277958 NM_001277959 NM_021466 RefSeq (protein) NP_001188465 NP_005672 NP_647603 NP_001264886 NP_001264887 NP_001264888 NP_067441 Location (UCSC) Chr 1: 222.56 – 222.59 Mb Chr 1: 183.17 – 183.19 Mb PubMed search [3] [4]
Wikidata
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Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as selective factor 1 (SL1), binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.^[6]

Interactions

TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A^[7] and Protein SET.^[7]