TAFA5

Chemokine-like protein TAFA-5 is a protein that in humans is encoded by the TAFA5 gene.^[5][6]

TAFA5
Identifiers
Aliases	TAFA5, QLLK5208, TAFA-5, UNQ5208, family with sequence similarity 19 (chemokine (C-C motif)-like), member A5, family with sequence similarity 19 member A5, C-C motif chemokine like, TAFA chemokine like family member 5, FAM19A5
External IDs	OMIM: 617499; MGI: 2146182; HomoloGene: 22888; GeneCards: TAFA5; OMA:TAFA5 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.32 Start 48,489,553 bp[1] End 48,850,912 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E3 Start 87,428,500 bp[2] End 87,643,565 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis tibial nerve hypothalamus amygdala hippocampus proper entorhinal cortex Brodmann area 9 postcentral gyrus right frontal lobe superior frontal gyrus Top expressed in superior colliculus central gray substance of midbrain dorsal tegmental nucleus lateral septal nucleus nucleus of stria terminalis anterior amygdaloid area ventral tegmental area inferior colliculi dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity Cellular component membrane integral component of membrane extracellular region extracellular space Biological process regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25817 106014 Ensembl ENSG00000219438 ENSMUSG00000054863 UniProt Q7Z5A7 Q91WE9 RefSeq (mRNA) NM_015381 NM_001082967 NM_001252310 NM_134096 RefSeq (protein) NP_001076436 NP_056196 NP_001239239 NP_598857 Location (UCSC) Chr 22: 48.49 – 48.85 Mb Chr 15: 87.43 – 87.64 Mb PubMed search [3] [4]
Wikidata
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This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to CCL3, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.^[6]