CCL3

Mammalian protein found in Homo sapiens From Wikipedia, the free encyclopedia

CCL3

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.[5]

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CCL3
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Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3
External IDsOMIM: 182283; MGI: 98260; HomoloGene: 88430; GeneCards: CCL3; OMA:CCL3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002983

NM_011337

RefSeq (protein)

NP_002974

NP_035467

Location (UCSC)Chr 17: 36.09 – 36.09 MbChr 11: 83.54 – 83.54 Mb
PubMed search[3][4]
Wikidata
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Function

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes[6] through binding to the receptors CCR1, CCR4 and CCR5.[5]

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).[7][5]

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[8]

Interactions

CCL3 has been shown to interact with CCL4.[9] Attracts macrophages, monocytes and neutrophils.

See also

References

Further reading

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