TBCD

For the Telephony Binary-Coded Decimal digital encoding method, see Binary-coded decimal.

Tubulin-specific chaperone D is a protein that in humans is encoded by the TBCD gene.^[5]

TBCD
Identifiers
Aliases	TBCD, SSD-1, tfcD, tubulin folding cofactor D, PEBAT
External IDs	OMIM: 604649; MGI: 1919686; HomoloGene: 4368; GeneCards: TBCD; OMA:TBCD - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 82,752,042 bp[1] End 82,945,914 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 121,342,775 bp[2] End 121,507,990 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland apex of heart right hemisphere of cerebellum left lobe of thyroid gland canal of the cervix anterior pituitary right uterine tube granulocyte ectocervix ventricular zone Top expressed in epithelium of lens Epithelium of choroid plexus facial motor nucleus hair follicle Paneth cell stroma of bone marrow trigeminal ganglion endothelial cell of lymphatic vessel lacrimal gland condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chaperone binding GTPase activator activity protein binding beta-tubulin binding Cellular component cytoplasm lateral plasma membrane membrane bicellular tight junction adherens junction plasma membrane cell junction microtubule centrosome microtubule organizing center cytoskeleton Biological process negative regulation of cell-substrate adhesion negative regulation of microtubule polymerization adherens junction assembly protein folding bicellular tight junction assembly positive regulation of GTPase activity post-chaperonin tubulin folding pathway mitotic cell cycle cell morphogenesis involved in neuron differentiation tubulin complex assembly microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6904 108903 Ensembl ENSG00000278759 ENSG00000141556 ENSMUSG00000039230 UniProt Q9BTW9 Q8BYA0 RefSeq (mRNA) NM_001033052 NM_005993 NM_029878 RefSeq (protein) NP_005984 NP_084154 Location (UCSC) Chr 17: 82.75 – 82.95 Mb Chr 11: 121.34 – 121.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.^[5]

Interactions

TBCD has been shown to interact with ARL2.^[6][7]