ARL2

ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene.^[5][6][7]

ARL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DOE, 3DOF
Identifiers
Aliases	ARL2, ARFL2, ADP ribosylation factor like GTPase 2, MRCS1
External IDs	OMIM: 601175; MGI: 1928393; HomoloGene: 1260; GeneCards: ARL2; OMA:ARL2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,014,160 bp[1] End 65,022,184 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,184,404 bp[2] End 6,191,578 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment nucleus accumbens apex of heart caudate nucleus putamen tibial nerve right frontal lobe left coronary artery ascending aorta right auricle of heart Top expressed in muscle of thigh right ventricle yolk sac superior frontal gyrus dentate gyrus of hippocampal formation granule cell right kidney saccule primary visual cortex otic placode otic vesicle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding GTPase inhibitor activity protein binding GTPase activity GDP binding Cellular component cytoplasm centrosome lateral plasma membrane mitochondrial intermembrane space intracellular anatomical structure microtubule organizing center mitochondrial matrix mitochondrion cytoskeleton nucleus nucleolus Golgi apparatus cytosol focal adhesion cilium microtubule cytoskeleton Biological process tubulin complex assembly regulation of insulin secretion negative regulation of GTPase activity regulation of microtubule polymerization bicellular tight junction assembly positive regulation of microtubule polymerization cell cycle maintenance of protein location in nucleus positive regulation of cell-substrate adhesion centrosome cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 402 56327 Ensembl ENSG00000213465 ENSMUSG00000024944 UniProt P36404 Q9D0J4 RefSeq (mRNA) NM_001667 NM_001199745 NM_019722 RefSeq (protein) NP_001186674 NP_001658 NP_062696 Location (UCSC) Chr 11: 65.01 – 65.02 Mb Chr 19: 6.18 – 6.19 Mb PubMed search [3] [4]
Wikidata
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Function

• The ADP-ribosylation factor (ARF) genes are small GTP-binding proteins of the RAS superfamily. ARL2 is a member of a functionally distinct group of ARF-like genes.^[7]
• In photoreceptors, ARL2 participates in the trafficking of lipidated membrane-associated proteins.^[8]
• There is an evidence that increased activity of ARL2 protein is strongly correlated with increased mitochondria fusion, while loss of ARL2 activity results in a decreased rate of fusion.^[9]

Interactions

ARL2 has been shown to interact with Protein unc-119 homolog,^[10] TBCD^[11][12] and PDE6D.^[13][14]