TDRD7

Tudor domain-containing protein 7 is a protein that in humans is encoded by the TDRD7 gene.^[5][6]

TDRD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RCO
Identifiers
Aliases	TDRD7, CATC4, CTRCT36, PCTAIRE2BP, TRAP, tudor domain containing 7
External IDs	OMIM: 611258; MGI: 2140279; HomoloGene: 8618; GeneCards: TDRD7; OMA:TDRD7 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.33 Start 97,412,096 bp[1] End 97,496,125 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 45,965,334 bp[2] End 46,034,761 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa retinal pigment epithelium internal globus pallidus sperm pars reticulata monocyte duodenum testicle middle frontal gyrus Top expressed in epithelium of lens spermatid neural layer of retina seminiferous tubule spermatocyte retinal pigment epithelium granulocyte mucous cell of stomach intestinal villus jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mRNA binding protein binding protein N-terminus binding RNA binding Cellular component cytoplasm chromatoid body mitochondrial matrix ribonucleoprotein granule Biological process posttranscriptional regulation of gene expression cell differentiation lens fiber cell differentiation lens morphogenesis in camera-type eye spermatogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23424 100121 Ensembl ENSG00000196116 ENSMUSG00000035517 UniProt Q8NHU6 Q8K1H1 RefSeq (mRNA) NM_001302884 NM_014290 NM_001290475 NM_146142 NM_001355189 RefSeq (protein) NP_001289813 NP_055105 NP_001277404 NP_666254 NP_001342118 Location (UCSC) Chr 9: 97.41 – 97.5 Mb Chr 4: 45.97 – 46.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

In melanocytic cells TDRD7 gene expression may be regulated by MITF.^[7]

Gene polymorphism

Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown.^[8]

Interactions

TDRD7 has been shown to interact with TACC1.^[9]