TACC1

Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.^[4]

TACC1
Identifiers
Aliases	TACC1, Ga55, transforming acidic coiled-coil containing protein 1
External IDs	OMIM: 605301; MGI: 2443510; HomoloGene: 4575; GeneCards: TACC1; OMA:TACC1 - orthologs
Gene location (Mouse) Chr. Chromosome 8 (mouse)[1] Band 8|8 A2 Start 25,644,568 bp[1] End 25,746,604 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in gastrula otolith organ utricle decidua uterus dorsal striatum brown adipose tissue nucleus accumbens adrenal gland prefrontal cortex BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear receptor binding estrogen receptor binding glucocorticoid receptor binding retinoic acid receptor binding peroxisome proliferator activated receptor binding retinoid X receptor binding thyroid hormone receptor binding Cellular component midbody cytoskeleton membrane nucleus microtubule organizing center cytoplasm microtubule cytoskeleton Biological process cerebral cortex development cell division cell cycle cell population proliferation microtubule cytoskeleton organization mitotic spindle organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6867 320165 Ensembl ENSG00000147526 ENSMUSG00000065954 UniProt O75410 Q6Y685 RefSeq (mRNA) NM_001122824 NM_001146216 NM_006283 NM_001330521 NM_177089 NM_199323 RefSeq (protein) NP_001116296 NP_001139688 NP_001317450 NP_006274 NP_001339707 NP_001339708 NP_001339709 NP_001339710 NP_001339711 NP_001339712 NP_001339713 NP_001339714 NP_001339715 NP_001339716 NP_001339717 NP_001339718 NP_001339719 NP_001339720 NP_001339721 NP_001339722 NP_001339723 NP_001339724 NP_001339725 NP_001339726 NP_001339727 NP_001339728 NP_001339729 NP_001339730 NP_001339731 NP_001339732 NP_001339733 NP_796063 NP_955355 NP_001389770 NP_001389771 NP_001389772 Location (UCSC) n/a Chr 8: 25.64 – 25.75 Mb PubMed search [2] [3]
Wikidata
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Function

The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers.^[4]

Interactions

TACC1 has been shown to interact with:

• Aurora A kinase,^[5][6]
• Aurora B kinase,^[5]
• BARD1,^[7]
• CKAP5,^[6][8]
• LSM7,^[6][9]
• SNRPG,^[9] and
• TDRD7.^[6]