TLE2

Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.^[5][6]

TLE2
Identifiers
Aliases	TLE2, ESG, ESG2, GRG2, transducin like enhancer of split 2, TLE family member 2, transcriptional corepressor
External IDs	OMIM: 601041; MGI: 104635; HomoloGene: 20693; GeneCards: TLE2; OMA:TLE2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,997,639 bp[1] End 3,047,635 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 81,410,395 bp[2] End 81,426,679 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis tibial nerve right lobe of thyroid gland left lobe of thyroid gland left uterine tube parotid gland apex of heart sural nerve Top expressed in cerebellar cortex neural layer of retina medullary collecting duct lobe of cerebellum cerebellar vermis primary visual cortex internal carotid artery adrenal gland superior frontal gyrus molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transcription corepressor activity Cellular component nucleus focal adhesion nucleoplasm extracellular space nuclear body transcription regulator complex Biological process animal organ morphogenesis negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated Wnt signaling pathway negative regulation of canonical Wnt signaling pathway transcription, DNA-templated signal transduction beta-catenin-TCF complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7089 21886 Ensembl ENSG00000065717 ENSMUSG00000034771 UniProt Q04725 Q9WVB2 RefSeq (mRNA) NM_001144761 NM_001144762 NM_001300846 NM_003260 NM_001252401 NM_019725 RefSeq (protein) NP_001138233 NP_001138234 NP_001287775 NP_003251 NP_001239330 NP_062699 Location (UCSC) Chr 19: 3 – 3.05 Mb Chr 10: 81.41 – 81.43 Mb PubMed search [3] [4]
Wikidata
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Interactions

TLE2 has been shown to interact with TLE1^[7] and HES1.^[7]