TLK1

Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene.^[5][6][7]

TLK1
Identifiers
Aliases	TLK1, PKU-beta, tousled like kinase 1
External IDs	OMIM: 608438; MGI: 2441683; HomoloGene: 130657; GeneCards: TLK1; OMA:TLK1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 170,990,823 bp[1] End 171,231,314 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C2 Start 70,542,751 bp[2] End 70,656,072 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus testicle Achilles tendon germinal epithelium epithelium of nasopharynx retinal pigment epithelium mucosa of sigmoid colon superficial temporal artery Epithelium of choroid plexus pars compacta Top expressed in hand superior cervical ganglion genital tubercle renal corpuscle tail of embryo blood medullary collecting duct piriform cortex foot otolith organ More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein serine/threonine kinase activity protein kinase activity protein binding ATP binding kinase activity Cellular component nucleus Biological process protein phosphorylation cell cycle intracellular signal transduction intracellular protein transport phosphorylation cellular response to DNA damage stimulus chromatin organization chromosome segregation peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9874 228012 Ensembl ENSG00000198586 ENSMUSG00000041997 UniProt Q9UKI8 Q8C0V0 RefSeq (mRNA) NM_001136554 NM_001136555 NM_012290 NM_172664 NM_001362963 RefSeq (protein) NP_001130026 NP_001130027 NP_036422 NP_766252 NP_001349892 Location (UCSC) Chr 2: 170.99 – 171.23 Mb Chr 2: 70.54 – 70.66 Mb PubMed search [3] [4]
Wikidata
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Function

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]^[7]

Interactions

TLK1 has been shown to interact with ASF1B,^[8][9] ASF1A^[8][10] and TLK2.^[11]