TOM1

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.^[5][6][7]

TOM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ELK, 1WRD, 2N2N
Identifiers
Aliases	TOM1, target of myb1 membrane trafficking protein, IMD85
External IDs	OMIM: 604700; MGI: 1338026; HomoloGene: 88453; GeneCards: TOM1; OMA:TOM1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 35,299,275 bp[1] End 35,347,992 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C1 Start 75,760,333 bp[2] End 75,796,749 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh skin of leg skin of abdomen monocyte apex of heart stromal cell of endometrium minor salivary glands left adrenal gland left adrenal cortex Top expressed in lens muscle tissue skeletal muscle tissue granulocyte lip muscle of thigh yolk sac quadriceps femoris muscle heart testicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin binding protein binding Cellular component cytosol endosome early endosome extracellular exosome intracellular anatomical structure cytoplasm membrane plasma membrane azurophil granule membrane specific granule membrane Biological process intracellular protein transport endocytosis endosomal transport protein transport neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10043 21968 Ensembl ENSG00000100284 ENSMUSG00000042870 UniProt O60784 O88746 RefSeq (mRNA) NM_001135729 NM_001135730 NM_001135732 NM_005488 NM_001136259 NM_011622 RefSeq (protein) NP_001129201 NP_001129202 NP_001129204 NP_005479 NP_001129731 NP_035752 Location (UCSC) Chr 22: 35.3 – 35.35 Mb Chr 8: 75.76 – 75.8 Mb PubMed search [3] [4]
Wikidata
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The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation. This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.^[7]

Interactions

TOM1 has been shown to interact with TOLLIP^[8] and ZFYVE16.^[9]