MCM5

DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.^[5][6][7]

MCM5
Identifiers
Aliases	MCM5, CDC46, P1-CDC46, minichromosome maintenance complex component 5, MGORS8
External IDs	OMIM: 602696; MGI: 103197; HomoloGene: 4904; GeneCards: MCM5; OMA:MCM5 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 35,400,134 bp[1] End 35,425,431 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C1 Start 75,836,197 bp[2] End 75,855,067 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence appendix granulocyte bone marrow cells lymph node spleen monocyte gonad rectum Top expressed in internal carotid artery external carotid artery primitive streak maxillary prominence mandibular prominence abdominal wall vas deferens Gonadal ridge endocardial cushion dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding DNA binding DNA helicase activity DNA replication origin binding chromatin binding protein binding hydrolase activity ATP binding helicase activity single-stranded DNA binding single-stranded DNA helicase activity 3'-5' DNA helicase activity Cellular component MCM complex membrane nucleus nucleoplasm cytoplasm cytosol Biological process G1 phase DNA replication cell cycle DNA duplex unwinding DNA replication initiation G1/S transition of mitotic cell cycle double-strand break repair via break-induced replication pre-replicative complex assembly involved in nuclear cell cycle DNA replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4174 17218 Ensembl ENSG00000100297 ENSMUSG00000005410 UniProt P33992 P49718 RefSeq (mRNA) NM_006739 NM_008566 NM_001302540 RefSeq (protein) NP_006730 NP_001289469 NP_032592 Location (UCSC) Chr 22: 35.4 – 35.43 Mb Chr 8: 75.84 – 75.86 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.^[7]

See also

• Mini Chromosome Maintenance

Interactions

MCM5 has been shown to interact with:

• Cell division cycle 7-related protein kinase,^[8]
• MCM2,^[8][9]
• MCM3,^[8][9]
• MCM7,^[8][9][10]
• ORC2L,^[8]
• ORC6L,^[8] and
• STAT1.^[9][11]