TRA2B

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the TRA2B gene.^[5][6]

TRA2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQC, 2KXN, 2RRA, 2RRB
Identifiers
Aliases	TRA2B, Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B, transformer 2 beta homolog (Drosophila), transformer 2 beta homolog
External IDs	OMIM: 602719; MGI: 106016; HomoloGene: 20965; GeneCards: TRA2B; OMA:TRA2B - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.2 Start 185,914,558 bp[1] End 185,938,103 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B1|16 13.18 cM Start 22,063,299 bp[2] End 22,084,755 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura ventricular zone embryo visceral pleura endothelial cell ganglionic eminence amniotic fluid tibia epithelium of nasopharynx Top expressed in tail of embryo genital tubercle ventricular zone yolk sac embryo embryo spermatocyte neural layer of retina morula blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding mRNA binding protein binding poly-purine tract binding RNA binding protein domain specific binding pre-mRNA binding identical protein binding Cellular component nucleus nuclear inner membrane nucleoplasm spliceosomal complex ribonucleoprotein complex Biological process RNA splicing, via transesterification reactions RNA splicing cerebral cortex regionalization mRNA processing negative regulation of mRNA splicing, via spliceosome embryonic brain development mRNA splicing, via spliceosome positive regulation of mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome regulation of RNA splicing protein complex oligomerization cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6434 20462 Ensembl ENSG00000136527 ENSMUSG00000022858 UniProt P62995 P62996 RefSeq (mRNA) NM_001243879 NM_004593 NM_009186 NM_001330554 NM_001330555 RefSeq (protein) NP_001230808 NP_004584 NP_001317483 NP_001317484 NP_033212 Location (UCSC) Chr 3: 185.91 – 185.94 Mb Chr 16: 22.06 – 22.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TRA2B contains a poison exon whose inclusion is autoregulated by TRA2B protein. Proper regulation of poison exon inclusion in TRA2B is important for T cell fate.^[7]

Interactions

TRA2B has been shown to interact with RBMX.^[8]