RBMX

Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the RBMX gene.^[5][6][7]

RBMX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MB0, 2MKS
Identifiers
Aliases	RBMX, HNRNPG, HNRPG, RBMXP1, RBMXRT, RNMX, hnRNP-G, MRXS11, RNA binding motif protein, X-linked, RNA binding motif protein X-linked
External IDs	OMIM: 300199; MGI: 1343044; HomoloGene: 20494; GeneCards: RBMX; OMA:RBMX - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 136,848,004 bp[1] End 136,880,764 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A6 Start 56,428,890 bp[2] End 56,438,396 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence left ovary Achilles tendon right ovary canal of the cervix smooth muscle tissue body of uterus mucosa of ileum rectum Top expressed in saccule genital tubercle Rostral migratory stream ventricular zone ganglionic eminence tail of embryo otic vesicle otic placode neural layer of retina olfactory bulb More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding nucleic acid binding mRNA binding RNA binding chromatin binding protein domain specific binding identical protein binding single-stranded RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component catalytic step 2 spliceosome membrane supraspliceosomal complex nucleoplasm spliceosomal complex extracellular exosome nucleus extracellular space ribonucleoprotein complex Biological process mRNA splicing, via spliceosome positive regulation of mRNA splicing, via spliceosome mRNA processing transcription by RNA polymerase II regulation of alternative mRNA splicing, via spliceosome transcription, DNA-templated negative regulation of mRNA splicing, via spliceosome membrane protein ectodomain proteolysis osteoblast differentiation cellular response to interleukin-1 protein homooligomerization RNA splicing positive regulation of transcription by RNA polymerase II RNA metabolic process protein complex oligomerization mRNA splice site selection positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27316 19655 Ensembl ENSG00000147274 ENSMUSG00000031134 UniProt P38159 Q9WV02 RefSeq (mRNA) NM_001164803 NM_002139 NM_001166623 NM_011252 RefSeq (protein) NP_001158275 NP_002130 NP_001160095 NP_035382 Location (UCSC) Chr X: 136.85 – 136.88 Mb Chr X: 56.43 – 56.44 Mb PubMed search [3] [4]
Wikidata
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Function

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified but their biological nature has not been determined.^[7]

Interactions

RBMX has been shown to interact with SFRS10^[8] and CDC5L.^[9]