TRIB2

Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene.^[5][6][7][8] TRIB2 is a pseudokinase member of the (pseudoenzyme) class of signaling/scaffold proteins, possessing very low vestigial catalytic output in vitro and critical scaffolding signaling functions in cells.^[9] It is known to signal to canonical MAPK and AKT pathways and to regulate the ubiquitination of substrates with important functions in cell proliferation that control the cell ccyle. It has also been associated with various diseases, especially in human and murine blood and solid tumor models.^[10] Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target,^[11] and its three dimensional structure has been solved with the aid of stabilizing nanobodies ^[12] corroborating the potential for new approaches for drug targeting outside the highly degraded ATP site ^[13] and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation.^[14] Recent work has established a convincing link between targetable overexpression of TRIB2 and prostate cancer drug responses ^[15]

TRIB2
Identifiers
Aliases	TRIB2, C5FW, GS3955, TRB2, tribbles pseudokinase 2
External IDs	OMIM: 609462; MGI: 2145021; HomoloGene: 41445; GeneCards: TRIB2; OMA:TRIB2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.3 Start 12,716,910 bp[1] End 12,742,734 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 15,841,728 bp[2] End 15,866,923 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary ganglionic eminence right ovary tibial nerve trigeminal ganglion spleen paraflocculus of cerebellum renal medulla left adrenal gland ventricular zone Top expressed in Gonadal ridge cumulus cell vas deferens efferent ductule medial ganglionic eminence interventricular septum atrioventricular valve saccule retina endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity protein kinase inhibitor activity transcription factor binding mitogen-activated protein kinase kinase binding ubiquitin protein ligase binding ubiquitin-protein transferase regulator activity Cellular component cytoplasm cytoskeleton nucleus Biological process regulation of MAP kinase activity protein phosphorylation negative regulation of fat cell differentiation positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28951 217410 Ensembl ENSG00000071575 ENSMUSG00000020601 UniProt Q92519 Q8K4K3 RefSeq (mRNA) NM_021643 NM_144551 RefSeq (protein) NP_067675 NP_653134 Location (UCSC) Chr 2: 12.72 – 12.74 Mb Chr 12: 15.84 – 15.87 Mb PubMed search [3] [4]
Wikidata
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