TRIM29

Tripartite motif-containing protein 29 is a protein that in humans is encoded by the TRIM29 gene.^[5][6]

TRIM29
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CSV
Identifiers
Aliases	TRIM29, ATDC, tripartite motif containing 29
External IDs	OMIM: 610658; MGI: 1919419; HomoloGene: 8100; GeneCards: TRIM29; OMA:TRIM29 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 120,111,286 bp[1] End 120,185,529 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.1 Start 43,222,145 bp[2] End 43,247,412 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh gums gingival epithelium mucosa of pharynx skin of arm skin of abdomen vulva human penis nipple oral cavity Top expressed in lip skin of external ear esophagus epidermis skin of abdomen skin of back hair follicle conjunctival fornix cornea middle ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity zinc ion binding p53 binding protein binding metal ion binding cadherin binding involved in cell-cell adhesion identical protein binding Cellular component intracellular anatomical structure cytoplasm lysosome Biological process negative regulation of protein localization to nucleus negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II cell-cell adhesion immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23650 72169 Ensembl ENSG00000137699 ENSMUSG00000032013 UniProt Q14134 Q8R2Q0 RefSeq (mRNA) NM_012101 NM_058193 NM_001330382 NM_023655 RefSeq (protein) NP_001317311 NP_036233 NP_076144 Location (UCSC) Chr 11: 120.11 – 120.19 Mb Chr 9: 43.22 – 43.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia–telangiectasia phenotype.^[6]

Interactions

TRIM29 has been shown to interact with TRIM23^[5] and GCC1.^[7]