TRIP6

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.^[5][6][7]

TRIP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X61, 2DLO
Identifiers
Aliases	TRIP6, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1, thyroid hormone receptor interactor 6
External IDs	OMIM: 602933; MGI: 1343458; HomoloGene: 37757; GeneCards: TRIP6; OMA:TRIP6 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,867,387 bp[1] End 100,873,454 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 137,307,916 bp[2] End 137,312,666 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus right lobe of thyroid gland palpebral conjunctiva canal of the cervix left uterine tube nipple ectocervix left lobe of thyroid gland ascending aorta gastric mucosa Top expressed in external carotid artery internal carotid artery vas deferens condyle ascending aorta efferent ductule aortic valve fossa vestibular membrane of cochlear duct dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase binding protein binding interleukin-1 receptor binding metal ion binding thyroid hormone receptor binding RNA binding Cellular component cell junction plasma membrane interleukin-1 receptor complex cytoskeleton nucleus focal adhesion cytoplasm cytosol stress fiber Biological process focal adhesion assembly cell adhesion regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of cell migration positive regulation of NIK/NF-kappaB signaling signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7205 22051 Ensembl ENSG00000087077 ENSMUSG00000023348 UniProt Q15654 Q9Z1Y4 RefSeq (mRNA) NM_003302 NM_011639 RefSeq (protein) NP_003293 NP_035769 Location (UCSC) Chr 7: 100.87 – 100.87 Mb Chr 5: 137.31 – 137.31 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[7]

Interactions

TRIP6 has been shown to interact with LPAR2,^[8] BCAR1^[8][9] and HOXA9.^[10]