TTI2

TELO2 interacting protein 2 is a protein that is encoded by the TTI2 gene in humans. ^[5]

TTI2
Identifiers
Aliases	TTI2, C8orf41, MRT39, TELO2 interacting protein 2
External IDs	OMIM: 614426; MGI: 2384576; HomoloGene: 11836; GeneCards: TTI2; OMA:TTI2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p12 Start 33,473,386 bp[1] End 33,513,185 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A3 Start 31,640,343 bp[2] End 31,654,730 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle ventricular zone gonad islet of Langerhans ganglionic eminence mucosa of transverse colon stromal cell of endometrium gastrocnemius muscle right testis left testis Top expressed in otic vesicle otic placode primitive streak saccule submandibular gland lumbar subsegment of spinal cord tail of embryo gastrula granulocyte ventricular zone More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 80185 234138 Ensembl ENSG00000129696 ENSMUSG00000031577 UniProt Q6NXR4 Q8BGV4 RefSeq (mRNA) NM_001102401 NM_001265581 NM_025115 NM_001330505 NM_001112729 NM_001199988 NM_144927 RefSeq (protein) NP_001095871 NP_001252510 NP_001317434 NP_079391 NP_001186917 NP_659176 Location (UCSC) Chr 8: 33.47 – 33.51 Mb Chr 8: 31.64 – 31.65 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1.

The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.