TUBA4A

Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene.^[5]

TUBA4A
Identifiers
Aliases	TUBA4A, H2-ALPHA, TUBA1, ALS22, tubulin alpha 4a
External IDs	OMIM: 191110; MGI: 1095410; HomoloGene: 68496; GeneCards: TUBA4A; OMA:TUBA4A - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 219,249,710 bp[1] End 219,277,902 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 75,190,872 bp[2] End 75,196,509 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium frontal pole muscle of thigh Brodmann area 10 skin of arm body of tongue nipple spinal ganglia gastrocnemius muscle Skeletal muscle tissue of rectus abdominis Top expressed in motor neuron ankle right ventricle aortic valve triceps brachii muscle vastus lateralis muscle sternocleidomastoid muscle tibiofemoral joint temporal muscle hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding structural constituent of cytoskeleton protein binding GTPase activity enzyme binding protein kinase binding Cellular component cytoplasm cytosol extracellular region microtubule extracellular exosome cytoskeleton microtubule cytoskeleton Biological process platelet degranulation G2/M transition of mitotic cell cycle microtubule-based process cytoskeleton organization ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle microtubule cytoskeleton organization mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7277 22145 Ensembl ENSG00000127824 ENSMUSG00000026202 UniProt P68366 P68368 RefSeq (mRNA) NM_001278552 NM_006000 NM_009447 NM_001313723 NM_001313724 RefSeq (protein) NP_001265481 NP_005991 NP_001300652 NP_001300653 NP_033473 Location (UCSC) Chr 2: 219.25 – 219.28 Mb Chr 1: 75.19 – 75.2 Mb PubMed search [3] [4]
Wikidata
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Function

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.^[6]

Interactions

TUBA4A has been shown to interact with NCOA6^[7] and APC.^[8]