TYRO3

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.^[5][6]

TYRO3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RHF
Identifiers
Aliases	TYRO3, BYK, Dtk, RSE, Sky, Tif, Etk-2, Rek, TYRO3 protein tyrosine kinase
External IDs	OMIM: 600341; MGI: 104294; HomoloGene: 4585; GeneCards: TYRO3; OMA:TYRO3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 41,557,675 bp[1] End 41,583,589 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E5|2 59.97 cM Start 119,628,214 bp[2] End 119,648,585 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole Brodmann area 10 paraflocculus of cerebellum middle frontal gyrus right hemisphere of cerebellum right frontal lobe Brodmann area 9 cerebellar vermis C1 segment cingulate gyrus Top expressed in primary motor cortex perirhinal cortex olfactory epithelium piriform cortex olfactory tubercle superior frontal gyrus entorhinal cortex cingulate gyrus prefrontal cortex primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity virus receptor activity kinase activity phosphatidylinositol 3-kinase binding protein binding protein heterodimerization activity ATP binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor tyrosine kinase transmembrane signaling receptor activity Wnt-protein binding Cellular component integral component of membrane nuclear envelope endoplasmic reticulum membrane membrane plasma membrane integral component of plasma membrane nucleus cell surface cytoplasm receptor complex Biological process vagina development phosphorylation negative regulation of lymphocyte activation protein phosphorylation viral entry into host cell phosphatidylinositol 3-kinase signaling protein autophosphorylation viral process signal transduction natural killer cell differentiation cell adhesion negative regulation of innate immune response spermatogenesis platelet activation forebrain cell migration apoptotic cell clearance substrate adhesion-dependent cell spreading peptidyl-tyrosine phosphorylation ovulation cycle negative regulation of neuron apoptotic process platelet aggregation neuron cellular homeostasis protein kinase B signaling negative regulation of toll-like receptor signaling pathway secretion by cell negative regulation of inflammatory response neuropeptide signaling pathway negative regulation of signal transduction Wnt signaling pathway cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7301 22174 Ensembl ENSG00000092445 ENSMUSG00000027298 UniProt Q06418 P55144 RefSeq (mRNA) NM_006293 NM_001330264 NM_001290800 NM_019392 RefSeq (protein) NP_001317193 NP_006284 NP_001277729 NP_062265 Location (UCSC) Chr 15: 41.56 – 41.58 Mb Chr 2: 119.63 – 119.65 Mb PubMed search [3] [4]
Wikidata
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Interactions

TYRO3 has been shown to interact with:

• GAS6,^[7][8] and
• PIK3R1^[9]