GAS6

Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

GAS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H30, 2C5D, 4RA0
Identifiers
Aliases	GAS6, AXLLG, AXSF, growth arrest specific 6
External IDs	OMIM: 600441; MGI: 95660; HomoloGene: 638; GeneCards: GAS6; OMA:GAS6 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 113,820,549 bp[1] End 113,864,076 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 6.06 cM Start 13,515,374 bp[2] End 13,544,490 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ascending aorta Descending thoracic aorta right uterine tube right coronary artery canal of the cervix apex of heart body of uterus left uterine tube popliteal artery tibial arteries Top expressed in stroma of bone marrow calvaria choroid plexus of fourth ventricle gallbladder ankle skin of external ear right kidney lip epithelium of stomach right lung More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding signaling receptor binding receptor tyrosine kinase binding voltage-gated calcium channel activity receptor ligand activity molecular adaptor activity phosphatidylserine binding metal ion binding protein tyrosine kinase activator activity calcium ion binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein-macromolecule adaptor activity Cellular component endoplasmic reticulum lumen cytoplasm Golgi lumen platelet alpha granule lumen extracellular exosome extracellular region intracellular anatomical structure extracellular space Biological process positive regulation of natural killer cell differentiation apoptotic cell clearance cellular response to vitamin K negative regulation of DNA-binding transcription factor activity positive regulation of protein kinase activity negative regulation of biomineral tissue development negative regulation of tumor necrosis factor-mediated signaling pathway cellular response to starvation positive regulation of phagocytosis positive regulation of protein kinase B signaling positive regulation of cytokine-mediated signaling pathway positive regulation of gene expression dendritic cell differentiation neuron migration cell adhesion protein kinase B signaling positive regulation of glomerular filtration B cell chemotaxis negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade phagocytosis regulation of growth activation of protein kinase B activity negative regulation of tumor necrosis factor production platelet degranulation viral entry into host cell negative regulation of oligodendrocyte apoptotic process leukocyte migration enzyme linked receptor protein signaling pathway positive regulation of protein tyrosine kinase activity cell migration platelet activation negative regulation of transcription, DNA-templated positive regulation of protein export from nucleus animal organ regeneration cellular response to growth factor stimulus negative regulation of interferon-gamma production macrophage cytokine production cellular response to glucose stimulus hematopoietic stem cell migration to bone marrow negative regulation of dendritic cell apoptotic process calcium ion transmembrane transport cell-substrate adhesion negative regulation of interleukin-6 production positive regulation of dendritic cell chemotaxis signal peptide processing viral genome replication cell population proliferation positive regulation of fibroblast proliferation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of fibroblast apoptotic process positive regulation of peptidyl-serine phosphorylation platelet aggregation positive regulation of TOR signaling peptidyl-serine phosphorylation endoplasmic reticulum to Golgi vesicle-mediated transport viral process extracellular matrix assembly cellular response to interferon-alpha protein phosphorylation negative regulation of renal albumin absorption negative regulation of endothelial cell apoptotic process positive regulation of protein phosphorylation signal transduction blood coagulation apoptotic process post-translational protein modification protein localization to plasma membrane regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2621 14456 Ensembl ENSG00000183087 ENSMUSG00000031451 UniProt Q14393 Q61592 RefSeq (mRNA) NM_001143946 NM_000820 NM_001143945 NM_019521 RefSeq (protein) NP_000811 NP_062394 Location (UCSC) Chr 13: 113.82 – 113.86 Mb Chr 8: 13.52 – 13.54 Mb PubMed search [3] [4]
Wikidata
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Function

Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.^[5]

Interactions

Gas6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3.^[6][7]

The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum. The action of vitamin K is essential on GAS6 function.^[8]