Transcription factor II E

Transcription factor II E (TF_IIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.^[1] It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.^[2]

general transcription factor IIE, polypeptide 1, alpha 56kDa
Identifiers
Symbol	GTF2E1
Alt. symbols	TF2E1
NCBI gene	2960
HGNC	4650
OMIM	189962
RefSeq	NM_005513
UniProt	P29083
Other data
Locus	Chr. 3 q21-q24
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general transcription factor IIE, polypeptide 2, beta 34kDa
Identifiers
Symbol	GTF2E2
Alt. symbols	TF2E2
NCBI gene	2961
HGNC	4651
OMIM	189964
RefSeq	NM_002095
UniProt	P29084
Other data
Locus	Chr. 8 p12
Search for Structures Swiss-model Domains InterPro

TF_IIE recruits TF_IIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TF_IIH. Both TF_IIH and TF_IIE are required for promoter clearance by RNA polymerase.^[2] Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes.^[3][4][5][6] TF_IIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.^[7]

See also

• TF_IIH
• TF_IIB
• TF_IID