Transcription factor II F

Transcription factor II F (TF_IIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.^[1][2][3]

general transcription factor IIF, polypeptide 1, 74kDa
Identifiers
Symbol	GTF2F1
Alt. symbols	TFIIF, BTF4, RAP74
NCBI gene	2962
HGNC	4652
OMIM	189968
RefSeq	NM_002096
UniProt	P35269
Other data
Locus	Chr. 19 p13.3
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general transcription factor IIF, polypeptide 2, 30kDa
Identifiers
Symbol	GTF2F2
Alt. symbols	TFIIF, BTF4, RAP30
NCBI gene	2963
HGNC	4653
OMIM	189969
RefSeq	NM_004128
UniProt	P13984
Other data
Locus	Chr. 13 q14
Search for Structures Swiss-model Domains InterPro

general transcription factor IIF, polypeptide 2-like
Identifiers
Symbol	GTF2F2L
Alt. symbols	TFIIF
NCBI gene	2964
HGNC	4654
RefSeq	NG_003013
Other data
Locus	Chr. 4 q31.22

TF_IIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes.^[4][5][6]

TF_IIF binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TF_IIF stabilizes the RNA polymerase II while it's contacting TBP and TF_IIB.

See also

• TF_IIA
• TF_IIB
• TF_IID
• TF_IIE
• TF_IIH