GTF2F2

General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene.^[5][6]

GTF2F2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BBY, 1F3U, 2BBY, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	GTF2F2, BTF4, RAP30, TF2F2, TFIIF, general transcription factor IIF subunit 2
External IDs	OMIM: 189969; MGI: 1915955; HomoloGene: 37884; GeneCards: GTF2F2; OMA:GTF2F2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.12-q14.13 Start 45,120,510 bp[1] End 45,284,893 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 76,134,377 bp[2] End 76,248,305 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone ganglionic eminence Achilles tendon muscle of thigh skin of abdomen testicle skin of leg Skeletal muscle tissue of biceps brachii gastrocnemius muscle Top expressed in embryo morula morula epiblast embryo uterus lens zygote spermatid cervix More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleotide binding helicase activity protein binding hydrolase activity ATP binding Cellular component microtubule cytoskeleton nucleoplasm transcription factor TFIIF complex nucleus transcription preinitiation complex Biological process mRNA splicing, via spliceosome regulation of transcription, DNA-templated transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II positive regulation of transcription initiation from RNA polymerase II promoter transcription, DNA-templated positive regulation of viral transcription transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway positive regulation of transcription elongation from RNA polymerase II promoter RNA metabolic process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2963 68705 Ensembl ENSG00000188342 ENSMUSG00000067995 UniProt P13984 Q8R0A0 RefSeq (mRNA) NM_004128 NM_026816 RefSeq (protein) NP_004119 NP_081092 Location (UCSC) Chr 13: 45.12 – 45.28 Mb Chr 14: 76.13 – 76.25 Mb PubMed search [3] [4]
Wikidata
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Interactions

GTF2F2 has been shown to interact with POLR2E^[7] and HTATSF1.^[8]

See also

• Transcription Factor II F