Translin

Translin is a DNA-binding protein that in humans is encoded by the TSN gene.^[5][6][7] Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).^[8][9][10]

TSN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J1J, 3PJA, 3QB5, 4WYV
Identifiers
Aliases	TSN, BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN, translin
External IDs	OMIM: 600575; MGI: 109263; HomoloGene: 3397; GeneCards: TSN; OMA:TSN - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.3 Start 121,737,103 bp[1] End 121,767,853 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.3 Start 118,222,508 bp[2] End 118,239,469 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad secondary oocyte skin of hip optic nerve skin of thigh ganglionic eminence thoracic diaphragm germinal epithelium islet of Langerhans superficial temporal artery Top expressed in trigeminal ganglion endothelial cell of lymphatic vessel Rostral migratory stream renal corpuscle primitive streak medullary collecting duct vestibular sensory epithelium neural tube Paneth cell superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nuclease activity endonuclease activity sequence-specific DNA binding protein binding mRNA binding hydrolase activity RNA binding single-stranded DNA binding identical protein binding endoribonuclease activity protein-containing complex binding Cellular component cytoplasm cytosol nucleus Biological process DNA recombination nucleic acid phosphodiester bond hydrolysis RNA metabolic process RNA phosphodiester bond hydrolysis, endonucleolytic production of siRNA involved in RNA interference Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7247 22099 Ensembl ENSG00000211460 ENSMUSG00000026374 UniProt Q15631 Q62348 RefSeq (mRNA) NM_001261401 NM_004622 NM_011650 RefSeq (protein) NP_001248330 NP_004613 NP_035780 Location (UCSC) Chr 2: 121.74 – 121.77 Mb Chr 1: 118.22 – 118.24 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.^[7]

Interactions

Translin has been shown to interact with PPP1R15A.^[11]